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Electrochemical determination of piroxicam on the surface of pyrolytic graphite electrode modified with a film of carbon nanoparticle-chitosan

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Abstract

The electrochemical behavior of the anti-inflammatory drug piroxicam is studied at the surface of a plain pyrolytic graphite electrode modified with chitosan-doped carbon nanoparticles. An electroactive surface was produced by drop-casting a suspension of the modifier and characterized by atomic force microscopy. A remarkable enhancement is found in studies on the cyclic voltammetric response towards piroxicam. This is described on the basis of the thin-layer mass transport regimes within the porous films, which leads to a considerable increase in the active surface area of the electrode. The electrode shows a linear response to piroxicam in the range of 0.05–50 μM, with a detection limit of 25 nM (at S/N of 3). The electrode was successfully applied to the determination of piroxicam in pharmaceutical and clinical preparations with satisfactory accuracy and precision.

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Acknowledgements

The authors gratefully acknowledge the support of the Research Council and the Center of Excellence for Nanostructures of the Sharif University of Technology, Tehran, Iran. They are grateful to Professor Mehdi Jalali-Heravi for his valuable suggestions.

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Authors and Affiliations

  1. Department of Chemistry, Sharif University of Technology, Tehran, 11155-9516, Iran

    Saeed Shahrokhian, Effat Jokar & Masoumeh Ghalkhani

  2. Institute for Nanoscience and Technology, Sharif University of Technology, Tehran, 14588-89694, Iran

    Saeed Shahrokhian

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  1. Saeed Shahrokhian
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  2. Effat Jokar
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Correspondence to Saeed Shahrokhian.

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Shahrokhian, S., Jokar, E. & Ghalkhani, M. Electrochemical determination of piroxicam on the surface of pyrolytic graphite electrode modified with a film of carbon nanoparticle-chitosan. Microchim Acta 170, 141–146 (2010). https://doi.org/10.1007/s00604-010-0373-6

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  • DOI: https://doi.org/10.1007/s00604-010-0373-6

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